Generic Equivalent To Flumadine
Active ingredients Rimantadin
Country of origin Russia
The tablets are white or almost white, round, flat, with a line on one side and chamfers on both sides.
Composition for 1 tablet:
- rimantadine hydrochloride - 50.0 mg;
Excipients: lactose monohydrate (milk sugar) - 98.4 mg; microcrystalline cellulose - 28.0 mg; croscarmellose sodium - 5.7 mg; povidone-K25 - 6.0 mg; magnesium stearate - 1.9 mg.
Rimantadine is taken orally (after meals) with water.
Treatment for influenza should be started within 24 to 48 hours after the onset of symptoms. Adults on the first day, 100 mg 3 times a day; on the second and third days, 100 mg 2 times a day; on the fourth and fifth day, 100 mg once a day. On the first day of therapy, it is possible to use the drug once in a dose of 300 mg.
Children aged 7 to 10 years, 50 mg 2 times a day; from 10 to 14 years old - 50 mg 3 times a day; over 14 years old - doses for adults. Course 5 days.
For the prevention of influenza: in adults, 50 mg once a day for up to 30 days; in children over 7 years old, 50 mg once a day for up to 15 days, depending on the epidemiological situation.
For the treatment and prevention of influenza in severe liver failure, epilepsy, elderly patients 100 mg 1 time per day.
When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension increase the risk of developing hemorrhagic stroke. With indications of a history of epilepsy and ongoing anticonvulsant therapy while using rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 100 mg per day simultaneously with anticonvulsant therapy. Prophylactic reception is effective in contact with sick people, with the spread of infection in closed groups and with a high risk of illness during an influenza epidemic.
The emergence of drug-resistant viruses is possible. Influence on the ability to drive transport. Wed and fur.: During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reaction.
Rimantadine reduces the effectiveness of antiepileptic drugs.
Adsorbents, astringents and coating agents reduce the absorption of rimantadine. Urine alkalizing agents (acetazolamide, sodium bicarbonate) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys. Urine acidifying agents (including ascorbic acid) reduce the effectiveness of rimantadine by increasing its excretion by the kidneys.
Paracetamol and ascorbic acid reduce the maximum plasma concentration of rimantadine by 11%.
Cimetidine reduces the clearance of rimantadine by 18%.
Rimantadine is active against various strains of influenza A. As a weak base, rimantadine acts by increasing the pH of endosomes, which have membrane vacuoles that surround viral particles after they enter the cell.
Prevention of acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of viral genetic material into the cytoplasm of the cell. Rimantadine also inhibits the release of viral particles from the cell, i.e. interrupts the transcription of the viral genome.
After oral administration, rimantadine is almost completely absorbed in the intestine.
Absorption is slow. The connection with plasma proteins is about 40%. Volume of distribution: adults - 17-25 l / kg, children - 289 l / kg. The concentration in the nasal secretion is 50% higher than the plasma concentration. The maximum concentration of rimantadine in blood plasma (Cmax) when taking 100 mg 1 time per day is 181 ng / ml, 100 mg 2 times a day is 416 ng / ml.
Metabolized in the liver. Half-life (T1 / 2) - 24-36 hours; excreted by the kidneys 15% - unchanged, 75-85% - in the form of metabolites.
In chronic renal failure, T1 / 2 doubles. In persons with renal insufficiency and in the elderly, it can accumulate in toxic concentrations if the dose is not adjusted in proportion to the decrease in creatinine clearance.
Early treatment and prevention of influenza A in adults and children over 7 years old.
hypersensitivity to rimantadine, drug components;
- hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption;
- acute liver disease;
- acute and chronic kidney disease;
- pregnancy and lactation;
- children under 7 years of age. With caution: use in case of arterial hypertension, epilepsy (including history), atherosclerosis of the cerebral vessels, with liver failure, elderly patients, diseases of the gastrointestinal tract.
Pregnancy and lactation: The use of rimantadine during pregnancy and during lactation is contraindicated
Symptoms: agitation, hallucinations, arrhythmias, stomach pains, irritability, insomnia, tremors, convulsions.
Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially excreted during hemodialysis.
From the nervous system: headache, dizziness, insomnia, nervousness, impaired concentration, drowsiness, anxiety, increased excitability, fatigue, ataxia, depression, euphoria, hyperkinesis, tremor, hallucinations, confusion, convulsions.
From the digestive system: epigastric pain, flatulence, dry mucous membrane floor
☆Different packaging design options are possible. Packing may be different, depends on the manufacturer. The composition of the tablets is the same. Medicine is made for the Russian market and has a the same design. Read the instructions on the Internet. Consult a doctor. Consider indications and contraindications for use.
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- Product Code: rimantadine
- Availability: In Stock
$8.90 - $107.90